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Drug delivery systems 5A. Oral drug delivery
1Action Medical Marketing Co., Libertyville, Illinois.
Journal of Clinical Pharmacology
|January 1, 1991
Summary
Controlled drug delivery systems offer consistent therapeutic drug levels and reduce dosing frequency. Oral systems enhance patient compliance and convenience, though biologic substances present challenges for this route.
Area of Science:
- Pharmaceutical Sciences
- Biomaterials Engineering
- Clinical Pharmacology
Background:
- Controlled drug delivery systems maintain optimal plasma drug concentrations via zero-order release, minimizing fluctuations and frequent dosing.
- Therapeutic systems enhance patient compliance by minimizing intervention and enabling controlled continuous drug release.
- Oral delivery systems require advancements in biocompatible materials, drug delivery modules, and understanding drug action under continuous administration.
Purpose of the Study:
- To review oral controlled-release drug delivery systems.
- To emphasize practical aspects of testing and fabrication.
- To explore mechanisms controlling drug release rates.
Main Methods:
- Review of existing literature on oral controlled-release drug delivery systems.
- Analysis of material science, bioengineering, and clinical pharmacology innovations.
- Examination of liposome technology for protecting substances in the stomach.
Main Results:
- Controlled drug delivery ensures therapeutic efficacy with reduced dosing and fewer side effects.
- Oral delivery offers convenience and cost-effectiveness but faces limitations with biologic substances and precise rate control.
- Liposome technology shows promise for protecting orally administered drugs.
Conclusions:
- Oral controlled drug delivery systems are a significant therapeutic modality for specific, well-controlled therapies and prophylaxis.
- Challenges remain in delivering biologic substances orally and achieving precise rate control.
- Future applications require careful consideration of drug interactions and individual patient variations.
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