Related Experiment Video
Updated: Jun 13, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Genes encoding carbocycle-forming enzymes involved in aminoglycoside biosynthesis in deep-sea environmental DNA
Hideyuki Tamegai1, Yumi Kanda, Chiaki Kato
1Department of Chemistry, College of Humanities and Sciences, Nihon University, Tokyo, Japan. htamegai@chs.nihon-u.ac.jp
Abstract:
We obtained 19 individual DNA fragments encoding 2-deoxy-scyllo-inosose synthase involved in the biosynthesis of aminoglycoside antibiotics from deep-sea sediments of the Pacific Ocean. Compared with genes from land-based environmental DNA, they showed low diversity. Combined with our previous study concerning the discovery of other aminoglycoside-biosynthetic genes from the same deep-sea samples, we suggest the importance of exploration of multiple biosynthetic genes to determine the diversity of aminoglycoside producers. We found that the deep sea is a useful source for screening of these genes.
Related Concept Videos
Inhibitors of Bacterial Protein Synthesis
Deep Sea Microbial Ecology
Biosynthesis in Bacteria
Biosynthesis of Nucleic Acids
Amino Acid Biosynthetic Pathways
Amino Acid Catabolism

