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Spectroscopic imaging with multidimensional pulses for excitation: SIMPLE.
D Spielman1, J Pauly, A Macovski
1Magnetic Resonance Systems Research Laboratory, Stanford University, California 94305.
Magnetic Resonance in Medicine
|May 1, 1991
Summary
New multidimensional pulses effectively suppress water signals for human brain proton spectroscopy and imaging. This technique improves in vivo imaging of brain tumors like astrocytoma by highlighting metabolic differences.
Area of Science:
- Magnetic Resonance Imaging
- Neuroimaging
- Biomedical Spectroscopy
Background:
- Proton spectroscopy and imaging in the brain necessitate suppression of water and lipid signals.
- Water suppression is challenging due to B0 and RF inhomogeneities, especially in large regions of interest (ROIs).
Purpose of the Study:
- To introduce and describe multidimensional selective-excitation pulses for defining ROIs and achieving water suppression in brain proton spectroscopy.
- To demonstrate the utility of these techniques for in vivo spectroscopic imaging.
Main Methods:
- Utilized multidimensional selective-excitation pulses (simultaneously selective along two axes) for spatial localization and water suppression.
- Developed pulse sequences for three-dimensional localization and water suppression robust to B0 and RF inhomogeneities.
Main Results:
- Acquired proton spectra and spectroscopic images (3.4 cc voxel) in 38 minutes.
- Observed clear spectral differences between normal and cancerous tissues in an astrocytoma patient.
Conclusions:
- Multidimensional selective-excitation pulses effectively define ROIs and suppress water signals in brain proton spectroscopy.
- These techniques enable in vivo spectroscopic imaging, differentiating between normal and cancerous brain tissues.