Related Experiment Video
Updated: Jun 13, 2026
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Determinants of Tc-99m sestamibi SPECT scan sensitivity in primary hyperparathyroidism
Todd W Swanson1, Simon K Chan, Steven J Jones
1Department of Surgery, St Paul's Hospital & University of British Columbia, Vancouver, BC, Canada.
Background:
The aim of this study was to evaluate the influence of patient and adenoma characteristics on (99m)Tc-methoxy isobutyl isonitrile (MIBI) scan performance in individuals diagnosed with primary hyperparathyroidism (PHP).
Methods:
Records of patients undergoing parathyroidectomy for PHP over 6 years at a single center were reviewed.
Results:
The overall true-positive (TP) rate for (99m)Tc-MIBI scans was 56%. Adenomas sized 1.9 to 3.5 cm were more likely to have TP scans than 0.3-cm to 1.8-cm adenomas (74% vs 40%, P < .001). Preoperative ionized calcium levels between 1.49 and 1.72 mmol/L were more likely to have TPs than levels between 1.27 and 1.48 mmol/L (65% vs 47%, P < .05). No single class of medication was shown to significantly effect TP rates. A decrease in TP rate was observed for larger adenomas in patients on >or=1 medication (74% vs 65%, P = .05).
Conclusions:
In PHP, (99m)Tc-MIBI scan positivity is most related to adenoma size and preoperative ionized calcium level.
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