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Left ventricular mass in hypertensive patients with mild-to-moderate reduction of renal function
Giovanni Cerasola1, Emilio Nardi, Giuseppe Mulè
1Chair of Internal Medicine, Department of Internal Medicine, Cardiovascular and Nephro-urological Diseases, European Society of Hypertension Excellence Centre, University of Palermo, Palermo, Italy. medint@unipa.it
Nephrology (Carlton, Vic.)
|May 18, 2010
Summary
Left ventricular hypertrophy (LVH) is more common in hypertensive patients with mild-to-moderate kidney dysfunction. This association between LV mass and declining kidney function is independent of other risk factors.
Area of Science:
- Cardiology
- Nephrology
- Hypertension Research
Background:
- Left ventricular hypertrophy (LVH) is a significant predictor of cardiovascular morbidity and mortality.
- Mild-to-moderate renal dysfunction is common in hypertensive patients.
Purpose of the Study:
- To investigate the relationship between left ventricular (LV) mass and renal function in non-diabetic hypertensive patients without cardiovascular disease.
- To assess LV mass in relation to glomerular filtration rate (GFR) in the Renal Dysfunction in Hypertension (REDHY) study cohort.
Main Methods:
- Excluded patients with diabetes, high BMI (>35 kg/m2), secondary hypertension, existing CV diseases, or GFR <30 mL/min/1.73 m2.
- Included 455 non-diabetic hypertensive patients for echocardiography and ambulatory blood pressure monitoring.
Main Results:
- A significant trend of increasing LV mass (indexed by BSA and height^2.7) was observed with declining GFR.
- LVH prevalence was higher in patients with lower GFR, remaining significant after adjusting for confounders.
- Multiple regression confirmed an independent inverse association between GFR and LV mass.
Conclusions:
- Mild-to-moderate renal dysfunction is associated with a high prevalence of LVH in hypertensive patients.
- The link between LV mass and GFR was independent of confounders like 24-hour blood pressure load.
- Further research is needed to understand LVH development mechanisms in chronic kidney disease.
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