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In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
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Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction

Arevik Mosoian1, Avelino Teixeira, Colin S Burns

  • 1Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. arevik.mosoian@mssm.edu

Proceedings of the National Academy of Sciences of the United States of America
|May 19, 2010
PubMed
Summary

Prothymosin-alpha (ProTalpha), a CD8+ T cell protein, activates Toll-like receptor 4 (TLR4) to induce type I interferons (IFN). This innate immune response potently suppresses HIV-1, offering new therapeutic strategies for viral infections.

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