Related Experiment Video

Updated: Jun 12, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

[Antiangionic drugs in soft tissue sarcoma]

S Salas1, T Huynh, J-L Deville

  • 1CHU La Timone, Service d'oncologie médicale, 13385 Marseille cedex 05, France.

Bulletin Du Cancer
|May 21, 2010
PubMed

Insights

Antiangiogenic drugs targeting vascular endothelial growth factor (VEGF) show promise for soft tissue sarcoma. Clinical trials evaluated the efficacy and safety of these novel VEGF inhibitors in patients.

Area of Science:

  • Oncology
  • Vascular Biology
  • Drug Development

Background:

  • Angiogenesis is crucial for soft tissue sarcoma growth and metastasis.
  • The vascular endothelial growth factor (VEGF) and its receptor (VEGFR) pathway is implicated in non-GIST soft tissue sarcoma development.
  • Anti-VEGF drugs have demonstrated efficacy in other solid tumors.

Purpose of the Study:

  • To evaluate the efficacy and safety of antiangiogenic drugs in soft tissue sarcomas.
  • To present the results of early-phase clinical trials for angiogenesis inhibitors in soft tissue sarcoma.
  • To explore the therapeutic potential of targeting the VEGF pathway in soft tissue sarcoma.

Main Methods:

  • Clinical trials were conducted to assess antiangiogenic therapies.
  • Bevacizumab (monoclonal antibody) and tyrosine-kinase inhibitors (small molecules) targeting VEGFR were evaluated.
  • Patient safety and treatment efficacy were primary endpoints.

Main Results:

  • Results from initial clinical trials on angiogenesis inhibitors in soft tissue sarcoma are presented.
  • Efficacy and safety data for anti-VEGF agents in soft tissue sarcoma patients were analyzed.
  • The study provides preliminary evidence on the role of angiogenesis inhibition in treating soft tissue sarcoma.

Conclusions:

  • Angiogenesis inhibitors represent a potential new therapeutic strategy for soft tissue sarcoma.
  • Further clinical investigation is warranted to establish the role of anti-VEGF therapies in soft tissue sarcoma treatment.
  • Bevacizumab and VEGFR inhibitors show potential for managing soft tissue sarcoma.

More Related Videos

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis09:33

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...