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Updated: Jun 12, 2026

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
Published on: January 23, 2018
Solvent-free and time-efficient Suzuki-Miyaura reaction in a ball mill: the solid reagent system KF-Al(2)O(3) under
Franziska Bernhardt1, Ronald Trotzki, Tony Szuppa
1Institute for Technical Chemistry and Environmental Chemistry, Friedrich-Schiller University Jena, Lessingstrasse 12, D-07743 Jena, Germany.
Abstract:
Although a plethora of synthetic procedures mediated by KF-loaded aluminas is available in the literature, there is almost no data concerning the influence of parameters such as alumina modification or KF-loading on experimental results. Hence, the Pd-catalyzed, solvent-free Suzuki-Miyaura reaction was chosen as model reaction to investigate the effect of the above mentioned parameters on the results of coupling reactions. The results from ball milling experiments led to the conclusion that self-prepared and commercially available KF-Al₂O ₃differ in water content. The higher the residual water content, the higher are the product yields.
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