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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Published on: January 22, 2018

Dysregulation of cellular signaling in gastric cancer

William K K Wu1, Chi H Cho, Chung W Lee

  • 1LKS Institute of Health, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, China. wukakei@cuhk.edu.hk

Cancer Letters
|May 22, 2010
PubMed

Insights

Gastric cancer pathogenesis involves complex signaling pathways. Targeting these pathways, including developmental ones, offers potential for new drug development, though their roles need further study.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling

Background:

  • Gastric cancer pathogenesis is multifactorial.
  • Dysregulated intracellular signaling pathways are common mechanisms.
  • Established oncogenic pathways (e.g., NF-κB, EGFR) and developmental pathways (e.g., TGF-β, Wnt) are implicated.

Purpose of the Study:

  • To review the role of intracellular signaling pathways in gastric carcinogenesis.
  • To highlight the significance of developmental signaling pathways in gastric cancer.
  • To provide a basis for targeted drug development.

Main Methods:

  • Literature review of signaling pathways in gastric cancer.
  • Analysis of established and emerging oncogenic pathways.
  • Discussion of developmental signaling pathways.

Main Results:

  • Multiple signaling pathways, including cell cycle regulators, NF-κB, COX-2, and EGFR, are involved in gastric carcinogenesis.
  • Developmental pathways such as TGF-β/BMP, Wnt/β-catenin, Hedgehog, and Notch signaling are increasingly recognized.
  • Cross-talk and relative importance of these pathways are not fully elucidated.

Conclusions:

  • Understanding these signaling pathways is crucial for developing targeted therapies for gastric cancer.
  • Further research is needed to clarify pathway interactions and their specific roles in gastric carcinogenesis.

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