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[Psoriasis: development and fatal complications].

P E Roth1, E Grosshans, H Bergoend

  • 1Clinique Dermatologique, Faculté de Médecine, Université Louis-Pasteur, Strasbourg, France.

Annales De Dermatologie Et De Venereologie
|January 1, 1991
PubMed
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Severe psoriasis can be fatal, particularly generalized pustular psoriasis and psoriatic polyarthritis. Complications from treatments and metabolic disorders are common causes of death in these severe skin disease cases.

Area of Science:

  • Dermatology
  • Internal Medicine
  • Medical Research

Background:

  • Severe psoriasis, including generalized pustular psoriasis and psoriatic erythroderma, can lead to lethal outcomes.
  • Psoriatic polyarthritis is frequently associated with severe psoriasis cases.
  • Complications from psoriasis treatments and metabolic disorders contribute to mortality.

Purpose of the Study:

  • To evaluate the incidence of fatal severe psoriasis cases in France over a 20-year period.
  • To identify the specific types of severe psoriasis and associated conditions linked to mortality.
  • To review the literature on lethal psoriasis outcomes and their causes.

Main Methods:

  • Retrospective study of psoriatic in-patients from 1965 to 1985.
  • Data collection from a dermatology clinic and other French dermatology departments.

Related Experiment Videos

  • Comprehensive literature review of reported fatal psoriasis cases over a century.

    • Main Results:

    • Seven deaths directly related to psoriasis or its therapy were observed among 992 in-patients.
    • An additional 39 fatal cases were identified from other French dermatology departments.
    • Generalized pustular psoriasis (18 cases) and psoriatic polyarthritis (18 cases) were prominent in fatal outcomes.
    • Metabolic disorders, infections, amyloidosis, and treatment complications were leading causes of death.
    • Literature review indicated 72 reported lethal psoriasis cases, with psoriatic polyarthritis in 55% of available fatal cases.

    Conclusions:

    • Severe psoriasis, especially generalized pustular forms and those with polyarthritis, carries a poor prognosis.
    • Mortality in severe psoriasis is often due to metabolic disorders, non-specific complications, or treatment side effects.
    • Rare pathologies like visceral amyloidosis and specific treatment complications are more frequently published than non-specific fatal outcomes.