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Updated: Jun 12, 2026

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue
Published on: October 1, 2008
Neurocupein from human brain
M V Mikaelyan1, R M Nalbandyan
1Institute of Biochemistry, Academy of Sciences of Armenian SSR, Yerevan, 375044, U.S.S.R.
Abstract:
The copper-containing protein, neurocuprein, has been obtained in a highly purified state from human brain. Many similarities in properties of neurocupreins from human and bovine brains are noted. These concern molecular weights, copper contents, isoelectric points, amino acid compositions, optical and EPR spectra as well as their reaction with catecholamines. However, it was found that the content of neurocuprein in the whole human brain is significantly (by a factor 2.5-3.0) higher than in bovine brain.
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