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Updated: Jun 12, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in
Lara G Chepenik1, Mariella Raffo, Michelle Hampson
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA. lara.chepenik@yale.edu
Abstract:
Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.
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