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Updated: Jun 12, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

G protein-coupled receptors function as logic gates for nanoparticle binding and cell uptake

Wolfgang Hild1, Klaus Pollinger, Andrea Caporale

  • 1Department of Pharmaceutical Technology, Center for Electron Microscopy at the Institute for Anatomy, University of Regensburg, 93053 Regensburg, Germany.

Proceedings of the National Academy of Sciences of the United States of America
|May 26, 2010
PubMed
Summary

Researchers developed a method to control nanoparticle interactions with cells using G protein-coupled receptors. This allows nanoparticles to either stay on the cell surface or be internalized for targeted diagnostics and drug delivery.

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G Protein-coupled Receptors

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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