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Published on: August 13, 2019
Alveolar ridge augmentation using implants coated with recombinant human growth/differentiation factor-5: histologic
Giuseppe Polimeni1, Ulf M E Wikesjö, Cristiano Susin
1Laboratory for Applied Periodontal & Craniofacial Regeneration, Department of Periodontics & Oral Biology, Medical College of Georgia School of Dentistry, Augusta, GA 30912, USA. gpolimeni@hotmail.com
Recombinant human growth/differentiation factor-5 (rhGDF-5) coated implants showed dose-dependent bone formation and osseointegration in dogs. The application of rhGDF-5 appears safe with minimal adverse effects, supporting its potential in oral implantology.
Area of Science:
- Oral surgery
- Biomaterials science
- Regenerative medicine
Background:
- Growth/differentiation factor-5 (GDF-5) shows potential for inducing bone formation.
- Recombinant human GDF-5 (rhGDF-5) is being investigated for enhanced bone regeneration.
- Oral implants require effective osseointegration and alveolar ridge augmentation.
Purpose of the Study:
- To evaluate rhGDF-5 coated oral implants for stimulating bone formation.
- To assess osseointegration and vertical alveolar ridge augmentation.
- To determine the safety and efficacy of rhGDF-5 in peri-implant defects.
Main Methods:
- Bilateral supraalveolar peri-implant defects were created in 12 dogs.
- Implants were coated with 30, 60, or 120 microg rhGDF-5, or left uncoated (control).
- Histologic evaluation with fluorescent bone markers was performed post-surgery.
Main Results:
- rhGDF-5 coated implants showed a dose-dependent increase in induced bone height.
- The 120 microg rhGDF-5 dose demonstrated more advanced peri-implant bone remodeling.
- All groups achieved clinically relevant osseointegration with no significant adverse effects.
Conclusions:
- rhGDF-5 coated oral implants exhibit osteoinductive and osteoconductive properties.
- Bone formation is enhanced by rhGDF-5, potentially influenced by local factors.
- rhGDF-5 application is safe and shows promise for improving oral implant outcomes.
