Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Tetanus01:29

Tetanus

Tetanus is a life-threatening neurological disorder characterized by persistent muscle contractions and spastic paralysis. It is caused by Clostridium tetani, a motile, Gram-positive, rod-shaped, obligate anaerobe. These bacteria produce terminal endospores, giving them a distinctive “lollipop” or “tennis-racket” appearance. They thrive in anaerobic environments, such as those found in deep puncture wounds.Once introduced into the body, the spores germinate into vegetative cells. These cells...
Antibiotic Selection00:57

Antibiotic Selection

Overview
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inclusive Search for Anomalous Single-Photon Production in MicroBooNE.

Physical review letters·2026
Same author

First Search for Dark Sector e^{+}e^{-} Explanations of the MiniBooNE Anomaly at MicroBooNE.

Physical review letters·2026
Same author

A two-mode thermomechanically squeezed phonon laser.

Nature communications·2026
Same author

First Measurement of Charged-Current Muon-Neutrino-Induced K^{+} Production on Argon Using the MicroBooNE Detector.

Physical review letters·2026
Same author

Pathological complete response with neoadjuvant pembrolizumab and chemotherapy in non-metastatic triple-negative inflammatory breast cancer.

ESMO open·2026
Same author

Measurement of the Positive Muon Anomalous Magnetic Moment to 127 ppb.

Physical review letters·2025
Same journal

Burkitt`s Lymphoma Presenting as Ileocolic Intussusception in a 8 year old boy.

Kathmandu University medical journal (KUMJ)·2026
Same journal

Negative Pressure Pulmonary Edema Following Septorhinoplasty.

Kathmandu University medical journal (KUMJ)·2026
Same journal

Corneal Deposits in a Jeweler: A case of ocular argyrosis.

Kathmandu University medical journal (KUMJ)·2026
Same journal

All on Four Implant Supported Denture -A zippy solution for complete edentulism.

Kathmandu University medical journal (KUMJ)·2026
Same journal

Eye Care Professionals' Knowledge, Attitude and Practice (KAP) on Myopia Management Approach: A Global Review.

Kathmandu University medical journal (KUMJ)·2026
Same journal

Breastfeeding Self-efficacy and Postnatal Depressive Symptoms: A Cross-sectional Study among Postnatal Women.

Kathmandu University medical journal (KUMJ)·2026
See all related articles

Related Experiment Video

Updated: Jun 12, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Ertapenem.

A Parakh1, S Krishnamurthy, M Bhattacharya

  • 1Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.

Kathmandu University Medical Journal (KUMJ)
|May 27, 2010
PubMed
Summary
This summary is machine-generated.

Ertapenem is a parenteral carbapenem effective for various community-acquired infections in adults and children over 3 months. Its stability against beta-lactamases and once-daily dosing make it suitable for mild to moderate cases and outpatient therapy.

Related Experiment Videos

Last Updated: Jun 12, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Antimicrobial Therapy

Background:

  • Ertapenem is a parenteral carbapenem antibiotic.
  • It exhibits activity against Gram-positive, Gram-negative, and anaerobic bacteria.
  • Ertapenem demonstrates stability against common beta-lactamases, including AmpC and extended-spectrum beta-lactamases.

Purpose of the Study:

  • To review the clinical efficacy and pharmacokinetic profile of ertapenem.
  • To assess its suitability for treating specific community-acquired infections.
  • To evaluate its role in outpatient parenteral antibiotic therapy.

Main Methods:

  • Review of randomized controlled trials and clinical data.
  • Analysis of pharmacokinetic properties and dosing regimens.
  • Evaluation of antimicrobial spectrum and stability against beta-lactamases.

Main Results:

  • Ertapenem is clinically and bacteriologically effective for complicated intra-abdominal infections, skin and skin-structure infections, pelvic infections, urinary tract infections, and community-acquired pneumonia.
  • It is also effective for surgical prophylaxis in elective colorectal surgery.
  • Favorable pharmacokinetics allow for once-daily intramuscular or intravenous administration.

Conclusions:

  • Ertapenem is a valuable option for treating mild to moderately ill patients with community-acquired infections.
  • Its properties support its use in outpatient intravenous antibacterial therapy.
  • Ertapenem offers a narrower spectrum compared to older carbapenems but possesses significant stability and convenient dosing.