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Circulating obestatin levels in normal and Type 2 diabetic subjects
D H St-Pierre1, F Settanni, I Olivetti
1Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, Molinette Hospital, University of Turin, Turin, Italy.
Journal of Endocrinological Investigation
|May 27, 2010
Summary
Obestatin levels are similar in fasting normal and Type 2 diabetes (T2D) patients. However, T2D patients do not show the expected decrease in obestatin after a meal, unlike normal subjects.
Area of Science:
- Endocrinology
- Metabolic Research
- Peptide Hormones
Background:
- Obestatin, a ghrelin gene product, influences insulin secretion, action, and adipocyte function.
- Obestatin secretion is known to be reduced by food intake in humans.
Purpose of the Study:
- To investigate obestatin secretion patterns in normal individuals and Type 2 diabetes (T2D) patients.
- To compare obestatin levels under basal conditions and following a standardized meal.
Main Methods:
- Studied 5 normal subjects and 5 T2D patients over 5 hours with a standardized meal at 0 minutes.
- Measured obestatin, glucose, and insulin levels at multiple time points before and after the meal.
Main Results:
- Fasting obestatin levels were comparable between normal and T2D subjects.
- Normal subjects exhibited a significant decrease in obestatin post-meal, while T2D patients showed no significant reduction.
Conclusions:
- Circulating obestatin levels are similar in fasting normal and T2D individuals.
- Type 2 diabetes patients appear resistant to the meal-induced inhibitory effect on obestatin secretion.
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