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Beckwith-Wiedemann syndrome and juvenile fibroadenoma: a case report

Melissa M Poh1, Tiffany N Ballard, J Jason Wendel

  • 1Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232-2345, USA.

Annals of Plastic Surgery
|May 28, 2010
PubMed

Insights

Beckwith-Wiedemann syndrome (BWS) patients, especially those with hemihypertrophy, face elevated tumor risks. This case highlights rapidly growing bilateral breast tumors in a 12-year-old girl with BWS, emphasizing rare occurrences and management considerations.

Area of Science:

  • Pediatric Endocrinology
  • Oncology
  • Genetics

Background:

  • Beckwith-Wiedemann syndrome (BWS) is a congenital overgrowth disorder.
  • Associated conditions include hemihypertrophy and increased cancer predisposition.
  • Early recognition is crucial for monitoring and management.

Observation:

  • A 12-year-old female with BWS and hemihypertrophy presented with rapidly enlarging bilateral breast tumors.
  • The tumors were asymmetric, posing a diagnostic challenge.
  • This presentation is uncommon in the existing literature.

Findings:

  • The case details the diagnostic process for breast tumors in an adolescent with BWS.
  • It underscores the importance of considering BWS in the differential diagnosis of breast masses in this population.
  • Management strategies for pediatric breast tumors in BWS are discussed.

Implications:

  • This report expands the understanding of BWS manifestations, specifically concerning breast tumors.
  • It provides insights into the differential diagnosis and treatment of breast masses in young females with BWS.
  • Highlights the need for tailored surgical and reconstructive approaches in developing adolescents.

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