Enhanced neural drive after maximal strength training in multiple sclerosis patients

Area of Science:

• Neurology
• Rehabilitation Medicine
• Exercise Physiology

Background:

• Multiple sclerosis (MS) is characterized by impaired muscle activation and lower limb strength.
• Strength training is known to improve muscle strength, but its effects on neural adaptations in MS patients are not well understood.

Purpose of the Study:

• To investigate the effects of maximal strength training (MST) on central neural drive and strength capacity in MS patients.
• To explore neural adaptations in the soleus muscle following MST.

Main Methods:

• 14 MS patients were randomized into an MST group or a control group (CG).
• The MST group underwent 3 weeks of high-load, low-repetition leg press and plantar flexion training.
• Neural adaptations were assessed using surface electromyography (EMG), H-reflexes, and V-waves during maximal voluntary contractions.

Main Results:

• The MST group showed a significant increase in maximal voluntary contraction (MVC) strength (20 +/- 9%).
• Soleus EMG activity and V/M ratio increased by 40% and 55% respectively in the MST group compared to CG.
• No significant changes were observed in the H/M ratio or in the control group.

Conclusions:

• Maximal strength training (MST) is effective in augmenting efferent motor output in MS patients.
• MST can alleviate neuromuscular symptoms associated with multiple sclerosis.
• This study provides evidence for the efficacy of MST as a rehabilitation strategy for MS.