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Related Experiment Video

Updated: Jun 12, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Smart lipids for programmable nanomaterials.

Matthew P Thompson1, Miao-Ping Chien, Ti-Hsuan Ku

  • 1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.

Nano Letters
|June 4, 2010
PubMed
Summary
This summary is machine-generated.

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Researchers developed novel DNA-programmed liposomes that change shape based on DNA interactions. This DNA-programmable nanotechnology allows for sequence-specific control over nanoscale structures, offering new possibilities in materials science.

Area of Science:

  • Nanotechnology and Materials Science
  • Biotechnology and Biomolecular Engineering

Background:

  • Liposomes are versatile nanoscale structures with applications in drug delivery and biomaterials.
  • Controlling liposome morphology is crucial for tailoring their function.
  • Current methods for liposome manipulation often lack specificity and reversibility.

Purpose of the Study:

  • To introduce novel, responsive liposomes assembled from DNA-programmed lipids.
  • To demonstrate sequence-selective manipulation of nanoscale morphology.
  • To establish a switchable system with programmability, specificity, and reversibility.

Main Methods:

  • Liposomes were assembled using DNA sequences conjugated to hydrophobic lipid tails.
  • Dynamic light scattering (DLS) was used to analyze aggregate size and changes.

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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

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Last Updated: Jun 12, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
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Published on: February 19, 2016

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Production of siRNA-Loaded Lipid Nanoparticles using a Microfluidic Device

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Published on: April 23, 2017

  • Transmission electron microscopy (TEM) and fluorescence microscopy visualized nanoscale morphology and DNA interactions.

    • Main Results:

    • DNA hybridization state directly influenced the sterics and electronics of the lipid head groups.
    • Liposome morphology was successfully and selectively manipulated based on DNA sequence complementarity.
    • The system demonstrated programmability, specificity, and reversibility in controlling liposome structure.

    Conclusions:

    • DNA-programmed lipids offer a novel approach to engineer responsive liposomes.
    • This platform enables precise, sequence-dependent control over nanoscale morphology.
    • The switchable nature of these liposomes opens avenues for dynamic nanomaterials and advanced delivery systems.