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Negative affectivity, self-referential processing and the cortical midline structures.

Cédric Lemogne¹, Philip Gorwood, Loretxu Bergouignan

¹CNRS USR 3246, Pitié-Salpêtrière Hospital, 47 boulevard de l'Hôpital, 75013 Paris, France. cedric-lemogne@orange.fr

Social Cognitive and Affective Neuroscience

|June 4, 2010

Summary

This summary is machine-generated.

Negative affectivity in healthy individuals is linked to heightened brain activity in self-referential areas. This increased neural activation, particularly in the dorsal medial prefrontal cortex, may explain the connection between negative emotions and self-focus.

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Area of Science:

Neuroscience
Psychology
Brain Imaging

Background:

The neural mechanisms linking negative affectivity and self-focus in healthy individuals are not well understood.
Cortical midline structures (CMS) are known to be involved in self-referential processing.

Purpose of the Study:

To investigate the association between negative affectivity and brain activation in CMS during self-referential processing in healthy subjects.
To explore the role of harm avoidance (HA) in modulating neural responses to self-related stimuli.

Main Methods:

Functional magnetic resonance imaging (fMRI) was used to scan 45 healthy participants.
Participants viewed positive and negative pictures, performing self-referential judgments and general judgments.
Negative affectivity was assessed using the harm avoidance (HA) scale from the Temperament and Character Inventory.

Main Results:

Self-referential processing activated CMS, including dorsal and ventral medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC).
Higher HA scores correlated with increased dorsal MPFC and PCC activation during self-referential tasks.
This heightened activation was more pronounced in the dorsal MPFC for negative stimuli.

Conclusions:

Increased CMS activation, particularly in the dorsal MPFC, may underlie the link between negative affectivity and self-focus in healthy individuals.
The dorsal MPFC might play a crucial role in integrating attention to negative stimuli and self-focus in negative affectivity.
Findings offer insights into the neural basis of self-focus in negative emotional states, potentially mirroring patterns seen in depression.