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A primate model of macular cyst
M X Repka1, N M Bressler, S A D'Anna
1Wilmer Ophthalmologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Ophthalmology
|April 1, 1991
Summary
Intravitreal injection of perfluoropropane gas (C3F8) in monkeys caused macular cysts, a novel finding. This model may aid research into cystoid macular edema treatments.
Area of Science:
- Ophthalmology
- Retinal Science
- Toxicology
Background:
- Expansile gases are used in vitreoretinal surgery.
- Potential ocular side effects require thorough investigation.
Purpose of the Study:
- To investigate the effects of perfluoropropane (C3F8) gas injection on primate macula.
- To establish a preclinical model for studying macular cyst development.
Main Methods:
- Perfluoropropane (C3F8) gas was injected into nine cynomolgus monkey eyes.
- Ocular changes were monitored using clinical examination and fluorescein angiography.
- Histopathologic evaluation was performed on six eyes.
Main Results:
- Macular cysts developed in all nine injected eyes within 3 months.
- No retinal vascular leakage was observed on fluorescein angiography.
- Histopathology revealed microcystic changes coalescing into larger cystic spaces in the macula.
Conclusions:
- Perfluoropropane (C3F8) gas can induce macular cysts in primate eyes.
- This model offers a new avenue for studying the pathogenesis of cystoid macular edema.
- Further research can explore interventional strategies using this model.