[Acute transfusion-related lung injury in patients after cardiac surgery]

to study the incidence of acute transfusion-related lung injury (TRALI) amongst cardiosurgical intensive care unit (ICU) patients and to assess the contribution of this pathology to the total number of postoperative pulmonary complications and its influence on the course and outcome of the underlying disease. 515 patients operated on for cardiovascular diseases at the N. N. Burdenko Main Military Hospital in 2005-2007 were retrospectively examined. A control group included 127 patients operated on without using donor blood preparations in the perioperative period. Ten cases of evolving acute lung injury (ALl) etiologically associated with transfusion therapy were found. One case of TRALI was fatal; the other cases required prolonged artificial ventilation (mean 36 +/- 2.5 hours), the length of their ICU stay increased by an average of 3.2 +/- 0.2 days as compared with that in the patients receiving no transfusion therapy. The development of ALI was etiologically associated with transfusion therapy in 23% of cases. The incidence of TRALI was 2.3%; mortality was 10%. At the same time, the majority of the detected cases were not timely recognized as TRALI. The latter required assisted/artificial ventilation and increased ICU stay length.