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Effects of oxygen concentration on the expression of an antioxidant gene in HepG2
Yasuko Sone1, Yasuko Kudo, Rieko Oba
1Institute of Environmental Science for Human Life, Ochanomizu University, Tokyo, Japan.
Bioscience, Biotechnology, and Biochemistry
|June 10, 2010
Abstract:
To clarify the effects of O(2) concentration (cO(2)) on antioxidant gene expression in human hepatocytes, mRNA expression of HepG2 cells cultured at 1, 3, and 5% cO(2) and atmospheric gas-phase, was measured. The expression of some genes fluctuated depending on the cO(2) in the incubator. This indicates that cO(2) is a critically important factor in the investigation of human biological mechanisms.
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