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Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
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Related Experiment Video

Updated: Jun 12, 2026

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
07:44

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

Synapse loss in dementias.

Ryan Clare1, Victoria G King, Martin Wirenfeldt

  • 1Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095-1732, USA.

Journal of Neuroscience Research
|June 10, 2010
PubMed
Summary
This summary is machine-generated.

Frontotemporal dementia (FTD) patients show significant synapse loss in the temporal lobe. This finding highlights synapse loss as a key factor in neurodegenerative diseases like FTD.

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Last Updated: Jun 12, 2026

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Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Area of Science:

  • Neuroscience
  • Neuropathology
  • Dementia Research

Background:

  • Synaptic transmission is crucial for nervous system function, and its impairment contributes to Alzheimer's-type dementia.
  • Synapse loss is a significant correlate of dementia severity, particularly in Alzheimer's disease (AD).
  • Synaptic decline is also observed in other dementias, including ischemic vascular dementia (IVD) subtypes.

Purpose of the Study:

  • To investigate synapse loss in frontotemporal dementia (FTD).
  • To quantify synaptophysin density in the temporal lobe of FTD patients.

Main Methods:

  • Utilized antigen-specific immunochemical methods for synaptic protein quantification.
  • Analyzed temporal lobe specimens from frontotemporal dementia (FTD) patients.

Main Results:

  • Demonstrated a significant loss of synaptophysin density in the temporal lobe of FTD patients.
  • Synaptophysin loss indicates substantial synaptic decline in FTD.

Conclusions:

  • Synapse loss is a key neuropathological feature of frontotemporal dementia (FTD).
  • Findings contribute to understanding dementia's diverse mechanisms.
  • Immunochemical methods are valuable for characterizing synapse loss in neurodegenerative diseases.