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Published on: January 22, 2016
Methylphenidate transdermal system in adults with past stimulant misuse: an open-label trial
Aimee L McRae-Clark1, Kathleen T Brady, Karen J Hartwell
1Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA. mcraeal@musc.edu
Objective:
This 8-week, open-label trial assessed the efficacy of methylphenidate transdermal system (MTS) in 14 adult individuals diagnosed with ADHD and with a history of stimulant misuse, abuse, or dependence.
Method:
The primary efficacy endpoint was the Wender-Reimherr Adult ADHD Scale (WRAADS), and secondary efficacy endpoints included the Clinical Global Impression (CGI) ratings and substance abuse as quantified by urine drug screens and self-reported use.
Results:
Significant improvements from baseline were found on both the WRAADS and CGI measurements. No abuse of the study medication was observed.
Conclusion:
The findings suggested that MTS may improve ADHD symptoms in adults with a history of stimulant misuse; however, there were limitations. The study data showed the need for subsequent randomized studies that further explore findings made in this study.
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