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Updated: Jun 12, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Rottlerin: bases for a possible usage in psoriasis.

Emanuela Maioli¹, Giuseppe Valacchi

¹Department of Physiology, University of Siena, Via Aldo Moro, 7-53100 Siena, Italy.

Current Drug Metabolism

|June 15, 2010

Summary

Rottlerin, a natural compound, shows potential for treating psoriasis due to its antioxidant, anti-inflammatory, and anti-proliferative properties. It effectively inhibits key pathways involved in this skin condition.

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Area of Science:

Pharmacology
Dermatology
Molecular Biology

Background:

Rottlerin is a natural polyphenolic compound.
It was initially marketed as a protein kinase C delta (PKCδ) inhibitor and is now patented as an antihypertensive drug.
Psoriasis is a skin disease marked by abnormal cellular proliferation, angiogenesis, and inflammation.

Purpose of the Study:

To review the potential therapeutic applications of Rottlerin in managing psoriasis.
To explore Rottlerin's antioxidant, antiproliferative, antiangiogenic, and anti-inflammatory activities.
To evaluate Rottlerin as a novel therapeutic strategy for psoriasis.

Main Methods:

Literature review of Rottlerin's properties and in vitro studies.
Analysis of Rottlerin's effects on cellular proliferation, angiogenesis, and inflammation.

Related Experiment Videos

Last Updated: Jun 12, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Investigation of Rottlerin's inhibitory action on nuclear factor kappa B (NF-κB).

Main Results:

Rottlerin exhibits antioxidant and anti-inflammatory effects.
It acts as a potent inhibitor of the transcription factor NF-κB.
Rottlerin demonstrates antiproliferative and antiangiogenic activities relevant to psoriasis.

Conclusions:

Rottlerin's multifaceted biological activities suggest its potential as a new therapeutic agent for psoriasis.
Its ability to modulate key pathways involved in psoriasis pathogenesis is promising.
Further research is warranted to validate Rottlerin's efficacy and safety in clinical settings.