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Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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Non-coding RNAs: Meet thy masters.

Fabrício F Costa1

  • 1Cancer Biology and Epigenomics Program, Children's Memorial Research Center and Northwestern University's Feinberg School of Medicine, 2300 Children's Plaza, Chicago, IL, USA. fcosta@childrensmemorial.org

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 15, 2010
PubMed
Summary
This summary is machine-generated.

New discoveries reveal that most of the eukaryotic genome is transcribed into non-coding RNAs (ncRNAs). Many of these ncRNAs are likely involved in epigenetic regulation, significantly impacting genomic science.

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Area of Science:

  • Genomics
  • Epigenetics
  • RNA Biology

Background:

  • Advanced DNA sequencing has revolutionized our understanding of eukaryotic genomes, epigenomes, and transcriptomes.
  • The identification of novel non-coding RNA (ncRNA) classes, like promoter-associated RNAs and long RNAs, has emerged.
  • It is now understood that up to 90% of eukaryotic genomes are transcribed, producing a vast array of non-coding RNAs.

Purpose of the Study:

  • To review recent advancements in the field of ncRNA research.
  • To highlight the emerging role of ncRNAs in epigenetic mechanisms and regulation.

Main Methods:

  • Review of current literature on ncRNA discovery and function.
  • Analysis of recent findings linking ncRNAs to epigenetic processes.

Main Results:

  • Eukaryotic genomes are broadly transcribed, with a significant portion yielding non-coding RNAs.
  • The functional roles of most ncRNAs remain largely uncharacterized.
  • Evidence suggests a substantial association between ncRNAs and epigenetic regulation.

Conclusions:

  • The discovery of numerous ncRNAs is reshaping the understanding of the eukaryotic gene pool.
  • ncRNAs are increasingly recognized as critical components of the epigenome.
  • Further research into ncRNA function is essential for a comprehensive understanding of gene regulation.