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[Study on HPLC-FPS of raw and processed fructus polygoni orientalis]
Yanjun Zhai1, Min Zhao, Hui Zhang
1Liaoning University of Traditional Chinese Medicine College of Pharmacy, Dalian 116600, China. lnzyzyj@sohu.com
A new HPLC fingerprint method was developed for Fructus Polygoni Orientalis, revealing significant chemical composition changes after processing. This method ensures quality control for the herb.
Area of Science:
- Pharmacognosy
- Analytical Chemistry
Context:
- Fructus Polygoni Orientalis is a traditional medicinal herb.
- Processing can alter its chemical constituents.
- Quality control is essential for its therapeutic efficacy.
Purpose:
- To develop and validate an HPLC fingerprint method for Fructus Polygoni Orientalis.
- To compare the chemical profiles of raw and processed Fructus Polygoni Orientalis.
- To use taxifolin as a reference standard.
Summary:
- An HPLC method with gradient elution at 270 nm was established.
- Twenty marker peaks were identified in raw samples and 33 in processed samples.
- The method demonstrated high similarity (>0.9), indicating stability and precision.
Impact:
- Provides a reliable quality control reference for Fructus Polygoni Orientalis.
- Highlights the chemical changes induced by processing.
- Supports the standardization of herbal medicines.
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