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Central nervous system action of endothelin-3 to inhibit water drinking in the rat
W K Samson1, K Skala, F L Huang
1Department of Anatomy and Neurobiology, University of Missouri School of Medicine, Columbia 65212.
Brain Research
|January 25, 1991
Abstract:
Endothelin-3, a vasoconstrictor peptide produced not only in endothelial cells but also within the brain interstitium in magnocellular neurons of the hypothalamo-neurohypophysial system, exerted significant, dose-related, inhibitory effects on water intake when administered into the third cerebroventricle of rats exposed to exogenous and endogenous stimuli for drinking. Passive immunoneutralization of endogenous endothelin-3 accentuated water drinking in response to angiotensin II administration suggesting a physiological role for the peptide in the central control of fluid and electrolyte homeostasis.