Related Experiment Video
Updated: Jun 12, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Thermoresponsive pore structure of biopolymer microspheres for a smart drug carrier
Kyunga Na1, Jaeyeon Jung, Jonghwan Lee
1Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul 151-742, Korea.
Abstract:
Triggering changes in surface porosity enabled the controlled release of biomolecules from elastin-like polypeptide (ELP) microspheres. The transition temperature (T(t)) of cross-linked microspheres was determined by differential scanning calorimetry, and T(t) was in agreement with the volume transition observed by changing the external temperature of the incubation media. The thermoresponsive pore structure of ELP microspheres and their surface morphology were examined by field-emission scanning electron microscopy. ELP microspheres were investigated as a smart drug carrier using model drug molecules, bovine serum albumin, and prednisone acetate. The release rate was accelerated by squeezing out the entrapped biomolecules as the temperature was increased above T(t) because of the development of micropores at the surface as well as in the bulk. In addition, the stepwise release confirmed that ELP microspheres could be progammed precisely to control the release of drugs by external stimuli.
More Related Videos
12:00Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process
Published on: March 21, 2014
09:09Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
Published on: February 27, 2016
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Stimuli-Activated
Modified-Release Drug Delivery Systems: Rate-Programmed II
Pore Transport and Ion-Pair Transport
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...
Modified-Release Drug Delivery Systems: Classification
Modified-Release Drug Delivery Systems: Site-Targeted