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Related Concept Videos

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...

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Related Experiment Video

Updated: Jun 12, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
08:32

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells

Published on: March 16, 2017

Light-controlled nitric oxide delivering molecular assemblies.

Salvatore Sortino1

  • 1Dipartimento di Scienze Chimiche, Universitá di Catania, Italy. ssortino@unict.it

Chemical Society Reviews
|June 18, 2010
PubMed
Summary
This summary is machine-generated.

Researchers are developing light-activated nitric oxide (NO) donors for controlled therapeutic delivery. These photodonors offer precise control over NO release, crucial for its various biological functions.

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Last Updated: Jun 12, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Photochemistry

Background:

  • Nitric oxide (NO) exhibits significant therapeutic potential as a bioregulatory, anticancer, antimicrobial, and antioxidant agent.
  • Precise control over NO release is critical due to its concentration and flux-dependent effects.
  • Developing controllable NO delivery systems is a key challenge in therapeutic applications.

Purpose of the Study:

  • To review recent advancements in the fabrication of light-responsive nitric oxide photodonors.
  • To highlight the design principles and biomedical relevance of NO-releasing molecular assemblies.
  • To inspire chemists, materials scientists, and biochemists in creating controllable NO dispensers.

Main Methods:

  • Assembly of NO photodonors into various molecular constructs.
  • Utilizing light as a non-invasive trigger for controlled NO release.
  • Fabrication of nanostructured films, polymers, gels, nanoparticles, and molecular conjugates.

Main Results:

  • Demonstrated the potential of light-responsive NO photodonors for on-demand NO delivery.
  • Showcased diverse molecular assemblies with promising biomedical applications.
  • Highlighted the importance of precise control over NO release for therapeutic efficacy.

Conclusions:

  • Light-triggered NO photodonors offer a versatile platform for controlled therapeutic NO delivery.
  • Molecular assemblies of NO photodonors show significant promise for practical biomedical applications.
  • Further research in this area can lead to innovative treatments leveraging NO's therapeutic properties.