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Updated: Jun 12, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Acute ototoxicity from a single infusion of oxaliplatin
Narinder K Malhotra1, Rizwan Aslam, Sydney P Lipman
1Regional Cancer Center, 5476 Pepperwood Circle, Erie, PA 16506, USA. pghmd02@aol.com
Abstract:
Ototoxicity secondary to the administration of the chemotherapeutic agent oxaliplatin is uncommon. We report a case of unilateral hearing loss that occurred immediately after the infusion of a single dose of oxaliplatin in a 70-year-old woman who was undergoing postoperative chemotherapy for rectal adenocarcinoma. To the best of our knowledge, no such case has been previously reported in the literature. The hearing loss in our patient was severe enough to limit her daily activities, and she experienced only minimal improvement during the next 2 years of follow-up.
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