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Updated: Jun 12, 2026

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

Alcohol and type 2 diabetes. A review.

A Pietraszek¹, S Gregersen, K Hermansen

¹Department of Endocrinology and Metabolism, Aarhus Sygehus THG, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, Denmark.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD

|June 18, 2010

Summary

Moderate alcohol consumption may lower type 2 diabetes (T2D) risk, but binge drinking increases it. Long-term alcohol use appears to improve glycemic control in T2D patients.

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Last Updated: Jun 12, 2026

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

Area of Science:

Endocrinology
Metabolic Diseases
Public Health

Background:

Type 2 diabetes (T2D) is a global health concern.
Alcohol consumption is prevalent and its metabolic effects are complex.
Understanding the relationship between alcohol and T2D is crucial for prevention and management.

Purpose of the Study:

To investigate the association between alcohol consumption and the risk of developing type 2 diabetes.
To evaluate the impact of alcohol on glycemic control in individuals with type 2 diabetes, considering different treatment regimens.

Main Methods:

Systematic literature search of MEDLINE and Cochrane Library for English-language studies.
Inclusion of meta-analyses, reviews, and observational studies (≥1000 participants) for T2D risk.
Inclusion of all relevant articles for glycemic control impact.

Main Results:

Most studies indicate a J-shaped association between alcohol intake and T2D incidence, with binge drinking increasing risk.
Acute alcohol intake does not cause hypoglycemia in diet-treated T2D patients but can in those on sulfonylureas.
Long-term alcohol use is generally associated with improved glycemic control in T2D.

Conclusions:

Alcohol consumption may reduce T2D incidence, though binge patterns elevate risk.
Hypoglycemia risk from acute alcohol intake is limited to sulfonylurea-treated T2D patients.
Long-term alcohol use may improve insulin sensitivity and glycemic control in T2D.