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Tracking miRNA Release into Extracellular Vesicles using Flow Cytometry
07:29

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Published on: October 6, 2023

Cellular phenotype switching and microvesicles.

Peter J Quesenberry1, Jason M Aliotta

  • 1Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, USA. pquesenberry@lifespan.org

Advanced Drug Delivery Reviews
|June 19, 2010
PubMed
Summary
This summary is machine-generated.

Cell-derived vesicles can alter target cell phenotypes, inducing stable epigenetic changes and functional effects. This discovery highlights cellular plasticity and offers potential for disease biomarkers and regenerative medicine.

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Last Updated: Jun 12, 2026

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Published on: October 6, 2023

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
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Published on: June 2, 2020

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06:03

Isolation and Characterization of Microvesicles from Peripheral Blood

Published on: January 6, 2017

Area of Science:

  • Cell Biology
  • Epigenetics
  • Regenerative Medicine

Background:

  • Cell-derived vesicles are increasingly recognized for their role in intercellular communication.
  • These vesicles can transfer molecules that modify the recipient cell's phenotype and function.

Purpose of the Study:

  • To explore the impact of cell-derived vesicles on target cell phenotype alteration.
  • To investigate the mechanisms and implications of vesicle-mediated epigenetic reprogramming.
  • To assess the clinical potential of cell-derived vesicles.

Main Methods:

  • Analysis of vesicle-mediated intercellular communication.
  • Investigation of epigenetic modifications induced by vesicle transfer.
  • Evaluation of functional outcomes in target cells.

Main Results:

  • Cell-derived vesicles induce stable phenotypic and functional changes in target cells.
  • Epigenetic reprogramming via transcriptional regulators is a key mechanism.
  • Vesicle cross-communication may explain stem cell plasticity, such as marrow conversion.

Conclusions:

  • Cell-derived vesicles represent a significant mechanism for cell fate determination and tissue regulation.
  • Vesicle-mediated epigenetic reprogramming offers insights into cellular plasticity.
  • Cell-derived vesicles show promise as biomarkers and in therapeutic applications for tissue restoration and cancer treatment.