Related Experiment Video

Updated: Jun 12, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Coronary collateral growth and its therapeutic application to coronary artery disease

Masatoshi Fujita1, Shigetake Sasayama

  • 1Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. mfujita@kuhp.kyoto-u.ac.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|June 19, 2010
PubMed

Insights

A well-developed coronary collateral circulation is functionally important. Increased shear stress, not ischemia, is the primary stimulus for collateral growth, offering therapeutic potential for angina.

Area of Science:

  • Cardiovascular Research
  • Physiology
  • Translational Medicine

Background:

  • Extensive data exists on coronary collateral circulation in animals and humans.
  • The functional significance of robust coronary collateral circulation is established.
  • The primary stimulus for collateral growth has shifted from ischemia to shear stress.

Purpose of the Study:

  • To review the mechanisms of coronary collateral growth.
  • To discuss the therapeutic potential of stimulating collateral growth for intractable angina.
  • To highlight the need for further research in this area.

Main Methods:

  • Review of experimental and clinical studies.
  • Analysis of the shift in understanding the principal stimulus for collateral growth.
  • Discussion of pharmacological and mechanical approaches to enhance collateral growth.

Main Results:

  • The functional importance of coronary collateral circulation is well-documented.
  • Increased shear stress is identified as the principal stimulus for coronary collateral growth.
  • Coronary collateral growth stimulation presents an alternative therapy for specific angina patients.

Conclusions:

  • Stimulating coronary collateral growth offers a therapeutic strategy for patients ineligible for standard interventions.
  • Further research is warranted to explore coronary collateral growth in myocardial ischemia models and human disease.
  • A well-developed collateral circulation may attenuate exercise-induced myocardial ischemia.

More Related Videos

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft05:25

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Published on: September 15, 2023

Related Concept Videos

Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...