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Quantitation of melphalan in plasma of patients by reversed-phase high-performance liquid chromatography with
L Silvestro1, I Viano, C Baiocchi
1Istituto di Farmacologia e Terapia Sperimentale, Università di Torino, Italy.
Journal of Chromatography
|February 15, 1991
Abstract:
An analytical procedure for the separation and determination of melphalan in human plasma was carried out. A simple high-performance liquid chromatographic method with electrochemical detection was developed taking advantage of the high sensitivity of the electrode redox reaction. The sample pretreatment consisted of a direct extraction of the interferents rather than of melphalan, owing to the difficulty of extraction of the drug, and was very simple, rapid and reproducible.