Related Experiment Video
Updated: Jun 12, 2026
09:53
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Pseudotumor cerebri: a new door opens for treatment
R Crosa1, O Marabotto, G Meehroff
1Department of Neurosurgery, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay - Rocrossa@adinet.com.uy.
Summary
Pseudotumor cerebri, a poorly understood condition, is linked to brain venous sinus stenosis. Our study found varied degrees of this stenosis in patients, with one treated successfully using a stent.
Area of Science:
- Neurology
- Vascular Medicine
- Medical Imaging
Background:
- Pseudotumor cerebri (PTC) is a rare neurological disorder.
- Its exact etiology remains largely unknown.
- Dural venous sinus abnormalities are increasingly implicated in PTC pathogenesis.
Purpose of the Study:
- To investigate the role of dural venous sinus alterations in pseudotumor cerebri.
- To present the experience of a multidisciplinary team in managing PTC patients.
- To evaluate the impact of venous sinus stenosis on PTC.
Main Methods:
- Retrospective analysis of 17 pseudotumor cerebri cases.
- Multidisciplinary team assessment, diagnosis, and treatment.
- Invasive pressure measurements to quantify venous sinus stenosis.
- Surgical intervention (stenting) in one case.
Main Results:
- All 17 patients exhibited varying degrees of dural venous sinus stenosis.
- Pressure measurements confirmed significant stenosis in affected sinuses.
- Successful stenting of the left lateral sinus was performed in one patient.
- Clinical improvement was observed post-intervention.
Conclusions:
- Dural venous sinus stenosis is a consistent finding in pseudotumor cerebri patients.
- Interventions targeting venous sinus stenosis may be beneficial for PTC.
- Further research is required to elucidate the causal relationship and optimize treatment strategies.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:14Increased Intracranial Pressure l: Introduction
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
01:22Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
01:29Increased Intracranial Pressure ll: Pathophysiology
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:19Cerebral Edema l: Introduction
Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...