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Updated: Jun 12, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
Published on: October 24, 2025
[New unifying diagnosis of functional diseases]
Per Fink1, Marianne Rosendal, Marie Lyngsaae Dam
1Forskningsklinikken for Funktionelle Lidelser og Psykosomatik, Arhus Universitetshospital, Arhus Sygehus, 8000 Arhus C, Denmark. per.fink@aarhus.rm.dk
Abstract:
Functional somatic symptoms are prevalent in all medical settings, but their management is hampered by an obsolete theoretical framework and inadequate classification systems. Epidemiological and neurobiological studies suggest that the functional somatic syndromes, e.g. fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome and somatoform disorders belong to the same family of disorders. An empirically based diagnosis including different subtypes and severities is proposed as a unifying diagnostic construct: bodily distress syndrome. This construct provides a common language for functional disorders across medical specialties.
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