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Related Experiment Video

Updated: Jun 12, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

Single versus multi-dose vaccine vials: an economic computational model.

Bruce Y Lee¹, Bryan A Norman, Tina-Marie Assi

¹Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA. BYL1@pitt.edu

|June 23, 2010

Summary

Single-dose vaccine formats reduce clinic waste but can increase costs. A computational model identifies optimal vial sizes based on daily patient demand for various vaccines, aiding procurement decisions.

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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

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Last Updated: Jun 12, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

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Published on: October 20, 2020

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Area of Science:

Vaccinology
Health Economics
Computational Modeling

Background:

Single-dose vaccine vials minimize clinic-level waste but may present higher production, disposal, and storage expenses compared to multi-dose formats.
Optimizing vaccine vial formats is crucial for balancing cost-effectiveness and minimizing wastage in diverse healthcare settings.

Purpose of the Study:

To develop a computational model for assessing the economic implications of single-dose versus multi-dose vaccine formats.
To guide vaccine developers, manufacturers, distributors, and purchasers in selecting cost-effective vaccine packaging.

Main Methods:

A computational model was created to analyze the economic impact of different vaccine vial formats.
The model determined mean daily patient arrival thresholds for various vaccine types to identify the most cost-effective format.

Main Results:

Patient demand significantly influences the cost-effectiveness of vaccine vial formats.
Specific daily patient thresholds were identified for measles (2), BCG (6), Hib (5), yellow fever (33), and pentavalent (5) vaccines, dictating optimal vial size selection.

Conclusions:

The choice between single-dose and multi-dose vaccine formats should be informed by patient volume to minimize overall costs.
This model provides valuable economic insights for vaccine procurement and supply chain management.