Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Birth Control Methods

Birth Control Methods

Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Conventional cardiac resynchronization therapy upgrading and its effect on functional mitral regurgitation in patients with pacing-induced cardiomyopathy.

Frontiers in cardiovascular medicine·2026

Same author

Improving Outcomes of CT-Guided Malignant Lung Lesion Microwave Ablation by Tract Sealing Using Venous Blood Clot.

Diagnostics (Basel, Switzerland)·2024

Same author

Improving <i>Clostridioides difficile</i> Infectious Disease Treatment Response via Adherence to Clinical Practice Guidelines.

Antibiotics (Basel, Switzerland)·2024

Same author

Clinical Features and Outcomes of VAP Due to Multidrug-Resistant <i>Klebsiella</i> spp.: A Retrospective Study Comparing Monobacterial and Polybacterial Episodes.

Antibiotics (Basel, Switzerland)·2023

Same author

Clinical Features and Outcomes of Monobacterial and Polybacterial Episodes of Ventilator-Associated Pneumonia Due to Multidrug-Resistant <i>Acinetobacter baumannii</i>.

Antibiotics (Basel, Switzerland)·2022

Same author

Ventilator-Associated Pneumonia due to Drug-Resistant <i>Acinetobacter baumannii</i>: Risk Factors and Mortality Relation with Resistance Profiles, and Independent Predictors of In-Hospital Mortality.

Medicina (Kaunas, Lithuania)·2019

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Combination of High Ligation and Intraoperative Embolization Using Polidocanol for Treatment of Varicoceles

Combination of High Ligation and Intraoperative Embolization Using Polidocanol for Treatment of Varicoceles

Published on: December 22, 2023

[Combined oral contraception and hypercoagulation].

Dalia Adukauskiene¹, Viktorija Miliauskiene

¹Department of Intensive Care, Kaunas University of Medicine, 50009 Kaunas, Lithuania. daliaadu@gmail.com

Medicina (Kaunas, Lithuania)

|June 24, 2010

Summary

Combined oral contraceptives (COCs) are effective but carry risks like deep-vein thrombosis, stroke, and myocardial infarction. Progestagen type significantly influences hypercoagulation risk, alongside estrogen dose.

Related Experiment Videos

Last Updated: Jun 12, 2026

Combination of High Ligation and Intraoperative Embolization Using Polidocanol for Treatment of Varicoceles

Combination of High Ligation and Intraoperative Embolization Using Polidocanol for Treatment of Varicoceles

Published on: December 22, 2023

Area of Science:

Reproductive Health
Pharmacology
Thrombosis Research

Context:

Combined oral contraceptives (COCs) have been a widely used contraceptive method for over five decades.
Despite their efficacy, COCs are associated with significant health risks.
These risks include venous thromboembolism, stroke, and myocardial infarction.

Purpose:

To review the safety profile of combined oral contraceptives.
To investigate the factors influencing the risk of hypercoagulation and venous thrombosis associated with COC use.
To highlight the roles of estrogen dose and progestagen type in adverse event occurrence.

Summary:

Combined oral contraceptives contain estrogens and progestagens, which can increase blood coagulation.
This heightened coagulation elevates the risk of deep-vein thrombosis, stroke, and myocardial infarction.
While estrogen dose is a known factor, recent research emphasizes the critical role of the specific progestagen type in thrombosis risk.

Impact:

Informing healthcare providers and patients about the risks associated with COCs.
Guiding the development of safer oral contraceptive formulations.
Potentially reducing the incidence of adverse cardiovascular and thrombotic events linked to oral contraceptive use.