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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

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Nonbalanced SSFP-based quantitative magnetization transfer imaging.

Monika Gloor1, Klaus Scheffler, Oliver Bieri

  • 1Division of Radiological Physics, Department of Medical Radiology, University of Basel Hospital, Basel, Switzerland. monika.gloor@stud.unibas.ch

Magnetic Resonance in Medicine
|June 24, 2010
PubMed
Summary
This summary is machine-generated.

Quantitative magnetization transfer (MT) imaging is now feasible with non-balanced steady-state free precession (SSFP) sequences, specifically using the SSFP free induction decay (SSFP-FID) method. This technique enables accurate MT parameter assessment in challenging tissues like musculoskeletal structures.

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Area of Science:

  • Biomedical Imaging
  • Magnetic Resonance Imaging (MRI)
  • Quantitative Imaging

Background:

  • Quantitative Magnetization Transfer (MT) imaging provides insights into tissue microstructure.
  • Traditional balanced steady-state free precession (SSFP) sequences struggle with quantitative MT in tissues exhibiting high magnetic susceptibility variations.
  • Off-resonance effects in balanced SSFP limit its application in areas like the musculoskeletal system.

Purpose of the Study:

  • To adapt quantitative MT imaging principles to non-balanced SSFP sequences.
  • To develop and validate an extended signal equation for SSFP free induction decay (SSFP-FID) applicable to tissues with high susceptibility variations.
  • To enable accurate assessment of quantitative MT parameters in challenging anatomical regions.

Main Methods:

  • Derivation of an extended SSFP free induction decay (SSFP-FID) signal equation based on a binary spin-bath model.
  • Application of the derived model to assess quantitative MT parameters: fractional pool size, magnetization exchange rate, and relaxation times.
  • Validation using ex vivo muscle, in vivo human femoral muscle, and in vivo human patellar cartilage samples.

Main Results:

  • The developed SSFP-FID method successfully derived quantitative MT parameters from various biological samples.
  • Comparison with two-pool balanced SSFP and existing quantitative MT models showed comparable or improved results for SSFP-FID.
  • The study addressed and discussed motion sensitivity issues inherent in SSFP sequences.

Conclusions:

  • Steady-state free precession free induction decay (SSFP-FID) is a viable method for quantitative MT imaging.
  • This technique is particularly effective for imaging targets with high susceptibility variations, such as musculoskeletal tissues.
  • SSFP-FID allows for rapid quantitative MT imaging, overcoming limitations of previous balanced SSFP approaches.