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Urinary incontinence in persons with Prader-Willi Syndrome
Alexander Von Gontard1, Robert Didden, Margje Sinnema
1Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany. alexander.von.gontard@uks.eu
BJU International
|June 26, 2010
Summary
Urinary incontinence is more common in individuals with Prader-Willi syndrome (PWS). This study found high rates of nocturnal enuresis and associated lower urinary tract symptoms, highlighting the need for targeted care.
Area of Science:
- Medical research
- Genetics
- Urology
Background:
- Prader-Willi syndrome (PWS) is a complex genetic disorder.
- PWS is associated with intellectual disability, obesity, and behavioral issues.
- Urinary incontinence (UI) is common in intellectual disability but understudied in PWS.
Purpose of the Study:
- To determine the prevalence and types of urinary incontinence (UI) in individuals with Prader-Willi syndrome (PWS).
- To identify associated lower urinary tract symptoms and behavioral issues in PWS patients.
Main Methods:
- A Dutch version of the 'Parental Questionnaire: Enuresis/Urinary Incontinence' was administered to 118 parents of children with PWS.
- The questionnaire assessed day/night wetting, toilet habits, voiding behaviors, UTIs, stool habits, and behavioral symptoms.
Main Results:
- Nocturnal enuresis affected 13.6% of individuals with PWS (mean age 15.1 years).
- Daytime urinary incontinence (3.8%) and fecal incontinence (3.3%) were also reported.
- Lower urinary tract symptoms, including overactive bladder and dysfunctional voiding, were common, as were behavioral problems.
Conclusions:
- Urinary incontinence is more prevalent in individuals with PWS compared to the general population.
- The high incidence of lower urinary tract symptoms necessitates thorough assessment and tailored treatment for UI in PWS care.
- Specific management strategies for UI should be integrated into the comprehensive care of individuals with PWS.
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