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Updated: Jun 12, 2026
08:18
Three-Dimensional Reconstruction of Orbital Fractures
Published on: May 16, 2025
Bilateral orbital bone infarction in sickle-cell disease
Roya H Ghafouri1, Irene Lee, Suzanne K Freitag
1Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts 02118, USA. roya.ghafouri@bmc.org
Ophthalmic Plastic and Reconstructive Surgery
|June 26, 2010
Summary
Sickle cell disease can cause orbital bone infarction, leading to eyelid swelling and eye movement issues. Prompt medical management is crucial for recovery and preventing complications.
Area of Science:
- Ophthalmology
- Hematology
- Pediatrics
Background:
- Sickle cell disease (SCD) is a genetic blood disorder predisposing individuals to vaso-occlusive crises.
- Orbital complications in SCD are uncommon but can be severe, impacting vision and ocular motility.
Observation:
- A 2-year-old boy with SCD presented with bilateral eyelid edema, restricted extraocular movements, and subperiosteal fluid.
- MRI revealed bilateral lateral orbital wall infarctions, consistent with bone infarction during a vaso-occlusive crisis.
Findings:
- Medical management including IV fluids, analgesics, antibiotics, and steroids led to clinical improvement.
- Orbital wall infarction in SCD patients can manifest as proptosis and limited eye motility.
Implications:
- Orbital wall infarction should be considered in SCD patients presenting with orbital symptoms.
- Early diagnosis and treatment are vital to prevent serious complications like orbital compression syndrome.
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