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Related Experiment Video

Updated: Dec 19, 2025

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization

Published on: December 25, 2017

"Drawing" upconversion nanophosphors into water through host-guest interaction.

Qian Liu¹, Chunyan Li, Tianshe Yang

¹Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.

Chemical Communications (Cambridge, England)

|June 26, 2010

Summary

Researchers developed a simple method to make hydrophobic upconversion nanophosphors biocompatible using beta-cyclodextrin and adamantaneacetic acid for bioimaging applications.

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Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Hydrophobic nanophosphors present challenges for in vivo applications.
Surface modification is crucial for enhancing biocompatibility and cellular uptake.

Purpose of the Study:

To develop a straightforward and efficient strategy for converting hydrophobic upconversion nanophosphors into biocompatible materials.
To enable the application of these modified nanophosphors in bioimaging.

Main Methods:

Utilized the self-assembly of beta-cyclodextrin and adamantaneacetic acid.
Surface functionalization of hydrophobic upconversion nanophosphors.

Main Results:

Successfully achieved the conversion of hydrophobic nanophosphors to a biocompatible state.
Demonstrated the potential for bioimaging applications.

Conclusions:

The self-assembly strategy offers a simple and effective route to biocompatible nanophosphors.
This approach facilitates the use of upconversion nanophosphors in biological and medical imaging.