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Bicuspid aortic valve disease.
Samuel C Siu1, Candice K Silversides
1Division of Cardiology, University of Western Ontario, London, Ontario, Canada. Samuel.Siu@lhsc.on.ca
Journal of the American College of Cardiology
|June 29, 2010
Summary
Bicuspid aortic valve (BAV) disease, the most common congenital heart defect, often involves the aorta. Adults with BAV disease have a normal life expectancy, but require lifelong monitoring due to potential complications.
Area of Science:
- Cardiology
- Genetics
- Pathobiology
Background:
- Bicuspid aortic valve (BAV) disease is the most prevalent congenital cardiac defect.
- It frequently co-occurs with other congenital heart conditions, notably ascending aorta dilation due to aortic media abnormalities.
- These aortic changes persist regardless of valve function (stenosis or incompetence).
Purpose of the Study:
- To review the current understanding of BAV disease pathology, genetics, and clinical manifestations.
- To focus on the presentation and management of BAV disease in adulthood.
- To highlight ongoing research and future directions in BAV disease treatment.
Main Methods:
- Literature review of recent studies on BAV disease.
- Synthesis of information on pathology, genetics, and clinical course.
- Focus on adult patient populations and long-term outcomes.
Main Results:
- BAV disease affects both the valve and the aorta, complicating surgical decisions.
- Adults with BAV disease generally have a normal life expectancy compared to the general population.
- Continued surveillance is crucial for patients with BAV, with or without surgical intervention.
Conclusions:
- Despite advancements, unanswered questions remain regarding BAV disease.
- Future research aims to refine medical treatment strategies and intervention timing.
- Understanding the disease's genetic and pathobiological underpinnings is key for improved patient care.
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