Related Experiment Video
Updated: Jun 12, 2026
12:37
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Large congenital melanocytic nevi: associated risks and management considerations
Jordan B Slutsky1, Jeffrey M Barr, Alisa N Femia
1Department of Dermatology, SUNY Stony Brook, Stony Brook, NY, USA.
Seminars in Cutaneous Medicine and Surgery
|June 29, 2010
Summary
Large congenital melanocytic nevi (LCMN) pose risks like melanoma and neurocutaneous melanocytosis. Management strategies depend on size, location, and satellite nevi to ensure optimal patient outcomes.
Area of Science:
- Dermatology
- Pediatric Oncology
- Medical Genetics
Background:
- Large congenital melanocytic nevi (LCMN) in neonates can cause significant parental and physician concern.
- Understanding associated medical risks and psychological stress is crucial for informed management.
Purpose of the Study:
- To provide a detailed analysis of the risks associated with LCMN.
- To discuss management and treatment options for LCMN.
Main Methods:
- Review of current data on LCMN complications.
- Analysis of risk factors including size, location, and satellite nevi.
- Discussion of management strategies: observation, MRI, and surgery.
Main Results:
- LCMN >20 cm, particularly >40-60 cm, carry the highest risk for melanoma (CM, ECM) and neurocutaneous melanocytosis (NCM).
- Trunk lesions increase CM risk; numerous satellite nevi elevate NCM risk.
- Management decisions require a risk-benefit analysis considering lesion characteristics and symptoms.
Conclusions:
- Individualized management plans are essential for LCMN.
- Informed decisions balance potential complications against treatment risks.
- Comprehensive understanding guides patient care and parental comfort.
More Related Videos
Related Concept Videos
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:14Changes in Skin Color: Clinical Perspectives
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
01:19Pigmentation
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
01:19Mitral Valve Prolapse III: Nursing Management
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
01:21Barrett Esophagus-II: Clinical Manifestations and Management
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...