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Published on: July 28, 2018
Accuracy of Voxel-Based and Algebraic Formula-Based Methods in Quantifying Cerebral Aneurysm Volume by 3D-Rotational
N F Fanning1, H M O'Dwyer, J A B Bowden
1Department of Neuroradiology, Beaumont Hospital, Beaumont Road, Dublin 9; Ireland - johnthornton@beaumont.ie.
Summary
Accurate cerebral aneurysm volume measurement is crucial for endovascular treatment. A voxel-based method using 3D digital subtraction angiography (DSA) is more accurate than algebraic formulae for quantifying aneurysm volume.
Area of Science:
- Neurosurgery
- Medical Imaging
- Biomedical Engineering
Background:
- Accurate cerebral aneurysm volume is vital for guiding embolization during endovascular treatment.
- Current methods often rely on algebraic formulae, which may not accurately reflect complex aneurysm geometries.
- 3D digital subtraction angiography (DSA) provides volumetric data but requires precise quantification methods.
Purpose of the Study:
- To evaluate the accuracy of a voxel-based volumetric method compared to algebraic formulae for quantifying cerebral aneurysm volume using 3D-DSA.
- To compare the accuracy of 3D-DSA derived volumes with true in-vitro volumes.
- To assess the clinical applicability of different volumetric measurement techniques in endovascular treatment planning.
Main Methods:
- Construction of 13 latex cerebral aneurysm models for in-vitro volume measurement using a micropipette.
- Performance of 3D-DSA on contrast-filled aneurysm models and 75 in-vivo cerebral aneurysms.
- Estimation of aneurysm volumes using an automated voxel-based method and traditional ellipsoid/cylindrical algebraic formulae.
- Statistical analysis including linear regression to compare methods and assess accuracy against true volumes.
Main Results:
- The voxel volume method demonstrated high accuracy in vitro, with a mean percentage deviation from true volume of 3.7 +/- 3.5%.
- Ellipsoid formulae significantly underestimated aneurysm volume (-11.2 +/- 13.6%), while cylindrical formulae overestimated it (42.6 +/- 35.7%).
- Similar discrepancies between methods were observed in the in-vivo study, indicating aneurysms do not conform to simple algebraic geometry.
Conclusions:
- The automated voxel-based method provides accurate quantification of cerebral aneurysm volume from 3D-DSA data.
- Algebraic formulae are unreliable for measuring aneurysm volumes due to complex in-vivo geometries.
- The voxel-based method is recommended for accurate aneurysm volume calculation in 3D-DSA for improved endovascular treatment planning.
