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Related Concept Videos

Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Determinants of Bacterial Pathogenicity and Virulence01:20

Determinants of Bacterial Pathogenicity and Virulence

Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
Hand hygiene01:23

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
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Updated: Jun 11, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

Biological agents for chronic wounds.

Robert S Kirsner1

  • 1Department and Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 N.W. 10th Avenue, RMSB, Room 2023-A, Miami, FL 33136, USA. rkirsner@med.miami.edu

American Journal of Clinical Dermatology
|July 1, 2010
PubMed
Summary
This summary is machine-generated.

Tumor necrosis factor alpha antagonists show promise for chronic wound healing. Further research is needed to confirm the efficacy of etanercept for pyoderma gangrenosum, venous leg ulcers, and pressure ulcers.

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Swine Model of Biofilm Infection and Invisible Wounds
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Protocol to Create Chronic Wounds in Diabetic Mice
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Swine Model of Biofilm Infection and Invisible Wounds
07:16

Swine Model of Biofilm Infection and Invisible Wounds

Published on: June 16, 2023

Area of Science:

  • Wound healing research
  • Immunomodulatory therapies

Background:

  • Chronic wounds present a significant clinical challenge.
  • Tumor necrosis factor alpha (TNF-a) plays a role in inflammation and tissue remodeling relevant to wound healing.
  • TNF-a antagonists are emerging as potential therapeutic agents.

Purpose of the Study:

  • To evaluate the potential of TNF-a antagonists, specifically etanercept, in managing chronic wounds.
  • To explore the efficacy of etanercept in conditions like pyoderma gangrenosum, venous leg ulcers, and pressure ulcers.

Main Methods:

  • Review of preliminary studies and case reports on TNF-a antagonists in wound healing.
  • Identification of a rationale for further clinical investigations.

Main Results:

  • Preliminary evidence suggests clinical potential for TNF-a antagonists in pyoderma gangrenosum.
  • A scientific basis exists for assessing etanercept's efficacy in venous leg ulcers and pressure ulcers.

Conclusions:

  • TNF-a antagonists, exemplified by etanercept, warrant extensive evaluation for chronic wound healing.
  • Further rigorous studies are essential to establish the role of etanercept in specific chronic wound types.