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Related Experiment Video

Updated: Jun 11, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

Functional implications of age differences in motor system connectivity.

Jeanne Langan¹, Scott J Peltier, Jin Bo

¹School of Kinesiology, University of Michigan Ann Arbor, MI, USA.

Frontiers in Systems Neuroscience

|July 1, 2010

Summary

This summary is machine-generated.

Older adults exhibit reduced brain lateralization during motor tasks due to corpus callosum (CC) degeneration. This impacts interhemispheric communication, leading to increased ipsilateral motor cortex activity and slower reaction times in older individuals.

Keywords:

aging corpus callosum fMRI functional connectivity motor cortex

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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Area of Science:

Neuroscience
Cognitive Aging
Neuroimaging

Background:

Older adults display diminished lateralized brain activity compared to younger adults.
Degeneration of the corpus callosum (CC) may disrupt interhemispheric inhibition, contributing to age-related brain activity changes.

Purpose of the Study:

To investigate the relationship between age-related differences in interhemispheric connectivity and functional brain activity during motor tasks.
To explore the impact of corpus callosum integrity on brain activation patterns in aging.

Main Methods:

Magnetic resonance imaging (MRI) was employed to assess resting-state functional connectivity.
Functional brain activation during a simple motor task was measured.
Corpus callosum (CC) area was quantified.

Main Results:

Older adults demonstrated smaller CC area compared to young adults.
Increased recruitment of the ipsilateral primary motor cortex (M1) was observed in older adults, correlating with longer reaction times.
Reduced resting interhemispheric connectivity was associated with greater ipsilateral M1 recruitment in older adults.

Conclusions:

Age-related decline in interhemispheric connectivity, potentially due to CC degeneration, impairs the ability to inhibit the non-dominant hemisphere during motor tasks.
This reduced inhibitory capacity negatively affects motor performance in older adults.