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Area of Science:

  • Pharmacology
  • Phytochemistry
  • Neuroscience

Background:

  • Human cultural evolution has identified plant natural products with selective physiological effects.
  • Cannabis sativa L. has a historical medicinal use and was key to discovering the endocannabinoid system.
  • Delta(9)-tetrahydrocannabinol (Delta(9)-THC) from Cannabis activates cannabinoid receptors CB1 and CB2.

Purpose of the Study:

  • To summarize and critically discuss recent findings on plant natural products interacting with the endocannabinoid system.
  • To highlight non-cannabinoid plant constituents that bind to and modulate CB receptors.
  • To explore plant compounds targeting enzymes involved in endocannabinoid regulation.

Main Methods:

  • Literature review and critical analysis of recent scientific findings.
  • Focus on plant natural products, including those from Cannabis and other species.
  • Examination of interactions with cannabinoid receptors (CB1, CB2) and endocannabinoid-regulating enzymes.

Main Results:

  • Several non-cannabinoid plant constituents have been identified that interact with CB receptors.
  • Plant natural products, beyond Cannabis, also target enzymes controlling endocannabinoid levels.
  • These findings expand the known repertoire of phytocompounds affecting the endocannabinoid system.

Conclusions:

  • Plant-derived compounds offer diverse interactions with the endocannabinoid system.
  • Further research into these phytocompounds may yield novel therapeutic applications.
  • The endocannabinoid system is a rich target for natural product drug discovery.